The association Between ALR2 -106C>T Gene Polymorphisms and Diabetic Retinopathy Susceptibility In Diabetes Mellitus Patient: A Systematic Review and Meta-Analysis
نویسندگان
چکیده
Aldose reductase gene polymorphisms has been indicated to be associated with diabetic retinopathy (DR). The research data were from PubMed and EMBASE. We identified -106C > T single nucleotide polymorphism (SNP). Pool odds ratio (OR) 95% CI calculated. Nine studies included. ALR2 106C was the increased risk of DR in T1DM (C vs. T, OR = 2.07, p 0.001; CC CT + TT, 2.56, 0.005). allele TT genotype decreased (OR 0.48, 0.0001 0.12, 0.0005). In conclusion, C may a factor, while serve as protective factor for patient.
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ژورنال
عنوان ژورنال: Ophtha Therapy
سال: 2023
ISSN: ['2543-9987', '2353-7175']
DOI: https://doi.org/10.24292/01.ot.230323.1